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- W2353473364 abstract "Objective To observe the effect of metformin on type 1 angiotensin II receptor ( AT1R) expression in endothelial cells and investigate its mechanism. Methods AT1 R,inhibitor protein κB ( I-κB) and AM P-activated protein kinase α( AM PKα ) protein expressions in endothelial cells were determined by Western blot,and nuclear factor-κB ( NF-κB) activation in endothelial cells was observed by con-focal laser scanning microscopy. The lactate dehydrogenase ( LDH) activation in the culture medium was detected by colorimetric assay. Also,the roles of NF-κB and AM PKα in the effect of metformin on AT1 R were determined by RNA interference technology. Results I-κB phosphorylation and AT1 R protein expression induced by tumor necrosis factor α ( TNFα) in endothelial cells were significantly reduced by metformin,and LDH activity in the endothelial cell culture medium was significantly decreased ( P 0. 01) . The inhibitory effect of metformin on AT1 R expression in endothelial cells was significantly reversed by AM PKαSiRNA ( P 0. 01) . Conclusion NF-κB activation and AT1 R expression can be inhibited by the intervention of metformin,and activation of the AM PKα pathway plays an important role in the beneficial effect of metformin on cardiovascular endothelial cells." @default.
- W2353473364 created "2016-06-24" @default.
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- W2353473364 date "2010-01-01" @default.
- W2353473364 modified "2023-09-25" @default.
- W2353473364 title "Effect of metformin on type 1 angiotensin II receptor expression in endothelial cells" @default.
- W2353473364 hasPublicationYear "2010" @default.
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