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• W2353473546 abstract "While initially effective, androgen deprivation therapy (ADT) is not curative, and nearly all men with advanced prostate cancer will eventually progress to the more resistant, and ultimately lethal form of the disease, so called castration-resistant prostate cancer (CRPC). The maintenance of androgens within the prostate cancer microenvironment likely represents one of the key mechanisms by which this transition from hormone-sensitive to CRPC occurs. This can be accomplished either through intratumoral androgen biosynthesis or the active transport of androgens and androgenic precursors into the tumor microenvironment. More recently, preclinical and clinical data supported therapeutic strategies that seek to target these two mechanisms, either through the use of drugs that impair androgen biosynthesis (e.g. inhibiting the steroidogenic enzymes CYP17 and AKR1C3 with abiraterone and indomethacin, respectively) or drugs that inhibit the SLCO transporters responsible for importing androgens (e.g. statins)." @default.
• W2353473546 created "2016-06-24" @default.
• W2353473546 creator A5014339741 @default.
• W2353473546 creator A5084909001 @default.
• W2353473546 date "2016-07-31" @default.
• W2353473546 modified "2023-10-03" @default.
• W2353473546 title "Targeting intratumoral androgens: statins and beyond" @default.
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• W2353473546 doi "https://doi.org/10.1177/1758834016647962" @default.
• W2353473546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4981288" @default.
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• W2353473546 hasPublicationYear "2016" @default.
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