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- W2353474578 abstract "Objective To study the Significance of the lipid profile and endothelium dependent vasodilatation function in the pathogenesis of microvascular angina Methods The concentration of plasma lipid, lipoprotein and apolipoprotein levels was assayed in 21 patients with microvascular angina and 24 healthy subjects The endothelium dependent vascodilatation function was also measured by high resolution ultrasound in the two groups Results (1)The serum total cholesterol (TC), LDL Cholesterol(LDL C), apolipoprotin B 100 (ApoB 100 ) and lipoprotein (a) levels in microvascular angina patients were significantly higher than those in healthy subjects (all P 0 05) (2) The flow mediated dilatation (FMD) in brachial arteries in microvascular angina patients was much lower compared with that in the healthy subjects[(4 7±1 9)% vs (12 8±3 7)%, P 0 001]. However, there was no significant difference in response to nitroglycerin between the two groups [(19 7±8 1)% vs (21 2±6 6)%, P 0 05] (3) Linear correlation analysis showed that FMD of brachial arteries was negatively correlated with the LDL C and Lp(a)( r = 0 512 5 and 0 427 1, respectively, P both 0 001) in microvascular angina All subjects were divided into two groups (group A and B) according to the degree of FMD of brachial arteries (The FMD of brachial arteries was ≤4% in group A and 4% in group B). The serum LDL C level in group A was significantly higher than that in group B [(4 09±0 65)mmol/L vs (2 59±0 49)mmol/L, P 0 05] Conclusion (1) TC, LDL C, ApoB 100 and Lp(a) levels in microvascular angina patients were significantly higher than those in healthy subjects (2) The disorder lipid profile and endothelium dependent vasodilatation dysfunction might play an important role in microvascular angina process (3) The endothelium dependent vasodilatation dysfunction in microvascular angina was mainly influenced by LDL C and Lp(a) in lipid profile, and myocardial endothelial dysfunction was aggravated by disorder lipid profile in microvascular angina" @default.
- W2353474578 created "2016-06-24" @default.
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- W2353474578 date "2002-01-01" @default.
- W2353474578 modified "2023-09-23" @default.
- W2353474578 title "The significance of the lipid profile and endothelium dependent vascodilatation function in the pathogenesis of microvascular angina" @default.
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