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- W2353476723 abstract "Objective:To investigate the influence of sodium selenite on the rats with autoimmune thyroiditis.Methods: Wistar rats were divided into three groups:normal control,experimental autoimmune thyroiditis (EAT) group and selenium cura- tio-EAT group.EAT model of rats were provocated,rats in the selenium curatio-EAT group were given a certain amount of sodi- um selenite by intragastric administration,and levels of flee thyroid hormones,autoantibodies and changes of histology of thyroid were observed.Results:At the end of the experiment,the levels of autoantibodies in the normal control,EAT group and selenium curatio-EAT group were(2.97±0.36),(3.14±0.18)%,(62.07±10.01),(51.5±5.91)%,(42.8±13.9),(35±5.64)%.In thegroup added sodium selenite,the levels of autoantibodies became much lower,and the lymph-cells in the thyroid were less serious and follicles were better.At the end of the experiment,FT3 and FT4 in the normal control,EAT group and selenium curatio-EAT group were (1.96±0.90),(3.01±1.21)%,(81.90±61.41),(41.94±20.35)%,(79.07±69.73 ),(17.72±3.22)%,FF4 in the selenium coratio-EAT group was lower than the EAT group(P□0.05).The levels of TSH did not change during the experiment(P□0.05 ).Conclusion: Sodium sdenite can inhibit the production of autoandbodies of EAT rats,protect the thyroid of rats,and make the levels of FT4 much lower." @default.
- W2353476723 created "2016-06-24" @default.
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- W2353476723 date "2007-01-01" @default.
- W2353476723 modified "2023-09-23" @default.
- W2353476723 title "Influence of Sodium Selenite on Rats with Autoimmune Thyroiditis" @default.
- W2353476723 hasPublicationYear "2007" @default.
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