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- W2353479928 abstract "OBJECTIVE To study the inhibitory effect of fluvastatin on the activity of T lymphocytes METHODS The activation and proliferation of T cells were examined by flow cytometric analysis Cytokine secretion was determined by ELISA TransAM TM ELISA kit was used to evaluate the activation of nuclear factor of activated T lymphocytes (NFAT) RESULTS 5 μmol·L -1 fluvastatin caused a lower level of CD69 expression, accompanied by an essential suppression of T cells proliferation, whereas no modification in CD25 expression was found Also, fluvastatin strongly blocked NFAT activation, and reduced IL 2 secretion, while the level of secreted IL 10 and IFN γ had no change, and the level of IL 4 even experienced a significant increase CONCLUSION Fluvastatin had inhibitory effect on the activity of T lymphocytes" @default.
- W2353479928 created "2016-06-24" @default.
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- W2353479928 date "2005-01-01" @default.
- W2353479928 modified "2023-09-25" @default.
- W2353479928 title "Effect of fluvastatin on the activity of human peripheral blood T lymphocytes" @default.
- W2353479928 hasPublicationYear "2005" @default.
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