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- W2353485240 abstract "ObjectiveTo investigate the effect and the mechanism of inducing apoptosis by Huangqi(Astragalus membranaceus) in Jurkat clone E6-1(Jurkat). MethodsAfter 120 hours effect of various concentrations of Huangqi(0-12.5 mg/ml), apoptosis in Jurkat was analysed by FCM. While at the concentration of 10 mg/ml, the activity of caspase 3, 9 and the level of Bcl-2 were compared with those without the effect of Huangqi by FCM. ResultsHuangqi induces apoptosis in Jurkat. When the dose of Huangqi was raised, vital cells decreased. At the concentration of 12.5 mg/ml, apoptotic rate reached its highest level(80.551.82)%, necrotic rate was(12.491.88)%. At the same time, Caspase 3 and caspase 9 in the cell line were activated. At the concentration of 10 mg/ml, the value of caspase 3 was from(0.570.16)% to(84.534.85)%, and caspase 9 was from(0.250.16)% to(20.724.87)%,and zVAD-fmk, the inhibitor of pan-caspases could inhibit the acivity of caspase 3 and caspase 9, and could also inhibit apoptosis. The value of Bcl-2 in Jurkat had no significant change under the action of huangqi. ConclusionHuangqi induces apoptosis of Jurkat independent on Bcl-2. Upregulation of caspase 3 and caspase 9 may play an important role in the process of apoptosis." @default.
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- W2353485240 date "2005-01-01" @default.
- W2353485240 modified "2023-09-24" @default.
- W2353485240 title "Apoptosis of Jurkat Clone E6-1 Induced by the Extract of Huangqi" @default.
- W2353485240 hasPublicationYear "2005" @default.
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