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- W2353489251 abstract "Objective To investigate the clinical effects of midazolam associated with fentanyl for sedation and amnesia during combined spinal-epidural analgesia. Methods sixty patients ASA physical status Ⅰ and Ⅱ undergoing gynecological operation were randomly divided into 3 grounds: Ground Ⅰ: fentanyl 1μg/kg +midazolam 0.03mg/kg. Gound Ⅱ: fentanyl 1μg/kg+midazolam 0.04mg/kg. Ground Ⅲ: fentanyl 1μg/kg+midazolam 0.05mg/kg. 1.8ml of 0.5% bupivacaine was injected into the subarachnoid space at the L3-L4 interspace, sensory block leve reached T8. patients received slowly intravenous midazolam and fentanyl 10 min before operation. Level of sedation was assessed using observer's estimation of alertness/sedation (OAA/S) scale in 5 min, 30 min, 60 min. Results OAA/S score in Ground Ⅰ was higher than that in Ground Ⅱ and Ground Ⅲ 10 min after intravenous sedative (P0.05); OAA / S score in Ground Ⅰ was higher than that in Ground Ⅱand Ground Ⅲ 10 min, 30min, 60min after intravenous sedative (P0.05 P0.01), table l. sedative in Ground Ⅲ has more obvious effect on amnesia than that in Group Ⅰ 30min and 120 min after intravenous sedative (P0.05) table 2. Conclusions sedative in Ground Ⅲ has obvious effect on amnesia and its effect was quick." @default.
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- W2353489251 date "2007-01-01" @default.
- W2353489251 modified "2023-09-25" @default.
- W2353489251 title "A clinical study of midazolam associated with fentanyl for sedation and amnesia during combined spinal-epidural analgesia" @default.
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