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- W2353491958 abstract "Objective To study the modulatory effect of Actinomycin D(Act D)on in down-reg- ulating cFLIP expression and promoting the apoptosis of colon cancer cell.Methods Flow cytometry scan(FACS)was employed to detectFas and cFLIP_L expression and the apoptosis of SW620 cell line pre- treated with Act D.The effect of cFLIP_L on apoptosis in SW620 cell line pretreated with Act D was also examined by FACS.Results After the SW620 cells were incubated with Act D( 10μg/L)for 24 h,the cFLIP_L expression was decreased obviously from 94.4% to 71.8%.At the same time,the apoptosis rate of 33.7% was observed in SW620 cell line induced by anti-Fas(1 mg/L).But Act D itself had no effect on the expression of Fas and the apoptosis of colon cancer cells.Conclusion Low dose Act D could signif- icantly down-regulate the expression of cFLIP protein in SW620 cells and obviously increase the apoptosis rate of colon cancer cells.Act D may be an ideal drug for regulating the expression of cFLIP in colon can- cer cells." @default.
- W2353491958 created "2016-06-24" @default.
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- W2353491958 date "2006-01-01" @default.
- W2353491958 modified "2023-09-26" @default.
- W2353491958 title "The effect of actinomycin D on the inhibition of apoptosis by cFLIP in coiorectal cancer cell" @default.
- W2353491958 hasPublicationYear "2006" @default.
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