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- W2353493310 abstract "Objective: To investigate the effect of systemic treatment with Zoledronate acid on healing of artificial bone grafts and osseointegration of dental implants in osteoporotic rats.Methods: Thirty female rats were randomly divided into three groups: sham-operated group(A),osteoporotic group(B) and zoledronate-treated group(C).Animals in group B and C received bilateral ovariectomy and group A underwent sham-operation.Twelve weeks after surgery,hydroxyapatite-coated titanium implants were inserted into proximal metaphyses of tibiae and bone defects were made near the implants with simultaneous transplant of Bio-oss particles.Animals in group C also received systemic Zoledronate acide treatment for 0.2mg/kg per three weeks,while animals in group A and B received saline injection.Animals were killed at 4 and 12 weeks after implant surgery and undecalcified sections were prepared and examined histologically and histomorphometrically.Results: At 4 weeks after implantation surgery,thickness of cortical bone(TCB),implant-bone contact rate(IBCR),new bone volume(NBV) and encompassing ratio of Bio-oss particles(ERBP) in group B were all significantly decreased when compared to group A and C;while most of bone indices in group C were significantly higher than those of group A(P0.01).At 12 weeks,all bone indices in group B were also significantly lower than those in group A and C,while most of bone indices in group C were similar to those of group A(P0.05),despite of TCB,which was slightly lower than group A(P0.05).Conclusion: While systemic treatment with Zoledronate Acid may resist the negative influence of osteoporosis and promotes bone graft healing and osseointagration of dental implants." @default.
- W2353493310 created "2016-06-24" @default.
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- W2353493310 date "2011-01-01" @default.
- W2353493310 modified "2023-09-26" @default.
- W2353493310 title "Systemic Treatment with Zoledronate Acid on Healing of Artificial Bone Graft and Osseointegration of Dental Implants in Osteoporotic Rats" @default.
- W2353493310 hasPublicationYear "2011" @default.
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