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- W2353500593 abstract "Objective:To study on the changes of hormones of hypothalamic pituitary thyroid axis,and nuclear T 3 receptors in hypothalamus cells thymus Tlymphocytes in rat model of spleen asthenia.Methods: Rhubarb decoction was used to develop adult SD rat model of spleen asthenia.32 rats were averagely divided into four groups at random:control group、spleen asthenia group、treatment group、spontaneous rehabilitation group.The immunoradiometric assay and the radioimmunoassay were applied to measure nuclear T 3 receptors in hypothalamus cells thymus T lymphocytes,and the hormones of hypothalamic pituitary thyroid axis of every rat.Result:①In spleen asthenia group and spontaneous rehabilitation group,rat T 3,T 4,FT 3,FT 4 serum levels,the contents of TRH hypothalamic,TSH pituitary levels,and the contents of nuclear T 3 receptors in hypothalamus cells and thymus T lymphocytes were markedly lower than those in control group,treatment group( P0.01 );And TRH,TSH serum levels,were markedly higher than those in control group,treatment group ( P0.01 );②The parameters between control group and treatment group had no significant difference ( P0.05 ). Conclusion:Impaired hypothalamic pituitary thyroid regulation function may be attributed to progression of spleen asthenia." @default.
- W2353500593 created "2016-06-24" @default.
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- W2353500593 date "2002-01-01" @default.
- W2353500593 modified "2023-09-23" @default.
- W2353500593 title "Impaired Hypothalamic-Pituitary-Thyroid Regulation Function and Changes of T_3 Receptors of Hypothalamus Cells & Thymus Tlymphocyte Nuclei in Rat Model of Spleen-Asthenia" @default.
- W2353500593 hasPublicationYear "2002" @default.
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