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- W2353529259 abstract "Objective To investigate the detecting ability of single photon emission computed tomography (SPECT) and CT in skull base invasion in nasopharyngeal carcinoma. Methods Sixty three patients with nasopharyngeal carcinoma were examined by whole body and skull base SPECT and CT of nasopharynx and skull base before radiotherapy. The results were double blind compared and evaluated. Results The overall positive rates of skull base invasion detected by SPECT and CT were 63.5% and 25.4%. In patients with headache, cranial nerve palsy and both, they were 87.9%,93.3%,92.3% and 42.4%,46.7%,46.2%. In patients with T 1+T 2 and T 3+T 4 lesions, they were 37.5%,90.3% and 0.0%,51.6%. In patients with N 0+N 1 and N 2+N 3 lesions, they were 63.9% ,63.0% and 19.4%,33.3%. The positive rates of SPECT were higher than those of CT (McNemar Test, P 0.05).The conformation rate between SPECT and CT was 61.9% and the dissimilitude rate was 38.1%. Binary Logistic regression analysis showed that headache and T stages were risk factors of positive SPECT rate(ORheadache=3.864, ORTstage 6.422),while Tstage and Nstage were the risk factors for positive CT rate(ORTstage=48.932,ORNstage=2.860 ). Conclusions The detection sensitivity of SPECT in skull base invasion in nasopharyngeal carcinoma is superior to that of CT. but its specificity is inferior to that of CT. The detecting results in SPECT are better related to symptoms, signs and stage. Combining headache and cranial nerve palsy with T and N stage, we may much improve the results of SPECT and CT in the detection of skull base invasion in nasopharyngeal carcinoma. Further study is warranted." @default.
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- W2353529259 date "2002-01-01" @default.
- W2353529259 modified "2023-09-23" @default.
- W2353529259 title "Comparison of SPECT and CT in detecting skull base invasion in nasopharyngeal carcinoma" @default.
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