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- W2353545702 abstract "Objective To assess the efficacy of recombinant human growth hormone (rhGH) in idiopathic growth hormone deficient (IGHD) children with the bone age (BA) of 13.0-17.0 years. Methods This was a noncomparative prospective study including 21 children who were divided into 2 groups according to their BA. BA of A group was 13.0-14.9 years, BA of B group was 15.0-17.0 years. A group consisted of 11 cases (8 boys and 3 girls), with an average chronological age (CA) (17.9±3.2)years and BA (13.5±0.6)years; B group was composed of 10 cases( 6 boys and 4 girls), with mean CA (18.7±2.1)years and BA (15.2±0.4)years.The body height SDS of A group and B group was -4.6±1.6 and -3.3±0.8 respectively,and the respective growth velocity of A group and B group was (2.6±1.1) and (2.3±0.9)cm /year before treatment.The enrolled children were treated with subcutaneous injection of rhGH (0.1 IU/kg) daily before sleep for six months. Results The mean height of A group and B group increased from (140.3±9.2) and (147.5±5.3)cm to (145.5±8.6) and (151.9±5.9)cm respectively. The growth velocity of A group and B group increased strikingly during 0-3 months,but the growth velocity of B group during 4-6 months decreased, being significantly lower than that of A group during 4-6 months(P0.05). There were no change in mean body weight and BA during the whole course of rhGH therapy.Serum insulin-like growth factor-Ⅰ and osteocalcin level increased strikingly in IGHD patients of B group after rhGH therapy (all P0.05). Conclusion rhGH appears to be an effective and safe drug in promoting the growth in IGHD with the BA of13.0-17.0years." @default.
- W2353545702 created "2016-06-24" @default.
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- W2353545702 date "2005-01-01" @default.
- W2353545702 modified "2023-09-26" @default.
- W2353545702 title "Application of recombinant human growth hormone in idiopathic growth hormone deficient children with bone ages between 13 and 17 years" @default.
- W2353545702 hasPublicationYear "2005" @default.
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