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- W2353560752 abstract "Objective To investigate the expression of COX-2 in gastric cancer and its relationship with angiogenesis and tumor cell proliferation. Methods Forty-three specimens resected from patients with gastric cancer were stained immunohistochemically for COX-2 expression. The angiogenesis and tumor cell proliferation were investigated by the immunohistochemical expression of factor Ⅷ and PCNA in tissue sections respectively. The intratumoral microvessel density (MVD) and PCNA index were counted and their relationship were analyzed. Results The expression of COX-2 was found in 60.5% of the specimens. Overexpression of COX-2 in gastric carcinoma was related to lymph node metastasis and clinical stage, but not to tumor size, depth of invasion and differentiation degree (P0.05). The MVD and PCNA indexes were significantly higher in the COX-2-positive tumors than those in the negative ones(P0.05).The expression of COX-2 was also correlated with MVD and PCNA index. Conclusion The expression of COX-2 may be play a role in neovascularization and tumor cell proliferation. It may serve as a prognosis factor and the guide for clinical decisions." @default.
- W2353560752 created "2016-06-24" @default.
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- W2353560752 date "2003-01-01" @default.
- W2353560752 modified "2023-09-24" @default.
- W2353560752 title "The expression of COX-2 in human gastric cancer and its relationship with neovascularization and tumor cell proliferation" @default.
- W2353560752 hasPublicationYear "2003" @default.
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