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- W2353572060 abstract "Objective:To compare the bioavailability between sodium selenite and selenoprotein in low selenium rats in the rang of nutrition level and study the dose-response relationship.Methods:72 Male SD rats were divided randomly into 9 groups according to weight,control group,Na2SeO3 4 groups and selenoprotein groups.All rats were fed in the selenium deficient diet in Keshan disease areas for 6 weeks.Control group rats were given purified water.Na2SeO3groups and selenoprotein groups were given selenium enriched substance including different dosage(2、4、8、16μg/kg bw)by intragastric administration for 4 weeks.Selenium content,glutathione peroxidase(GSH-Px)activity and thioredoxin reductase(TrxR)activity were tested to compare bioavailability.Results:Compared with control group,both selenium contents in blood,liver and kidney and the activity of GSH-Px and TrxR in liver and kidney were enhanced significantly with the increasing of selenium(P0.05).The selenium contents of liver and kidney in Na2SeO3groups were higher than selenoprotein groups in the same selenium level.However,the activity of GSH-Px and TrxR in selenoprotein groups were higher than Na2SeO3groups.Conclusion:Compared with Na2SeO3,selenoprotein can be effectively absorbed and utilized in low selenium rat." @default.
- W2353572060 created "2016-06-24" @default.
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- W2353572060 date "2010-01-01" @default.
- W2353572060 modified "2023-09-23" @default.
- W2353572060 title "Study on comparing the bioavailability between sodium selenite and selenoprotein in rats" @default.
- W2353572060 hasPublicationYear "2010" @default.
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