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- W2353579239 abstract "Objective:To explore the role of cytochrome c(cyt-c) in lung ischemia reperfusion injury and antagonism of puerarin on it.Methods:Rat lung model of ischemia reperfusion injury was established in vivo.Thirty Wistar rats were divided into three groups randomly:control group(group C),ischemia reperfusion group(group IR) and puerarin group(group Pur).The phenomenon of pulmonary apoptosis with TUNEL and the expression of cyt-c and caspase-3 with immunohistochemistry SP were studied.Results:①Expression of cyt-c and caspase-3 as well as AI in group IR were increased evidently compared with group C(P0.01);while the same changes happened in group Pur but less severely(P0.01).②The relation analysis indicated that the expression of cyt-c was strongly positively correlative to caspase-3 and apoptosis index(AI)(P0.01).Conclusion:Overexpression of cyt-c after lung ischemia reperfusion may play a significant role in the pathogenesis of lung injury,and puerarin may protect lung tissue by down-regulating expression of cyt-c." @default.
- W2353579239 created "2016-06-24" @default.
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- W2353579239 date "2010-01-01" @default.
- W2353579239 modified "2023-09-27" @default.
- W2353579239 title "Effect of cytochrome c in lung ischemia reperfusion injury and antagonism of puerarin on it" @default.
- W2353579239 hasPublicationYear "2010" @default.
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