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- W2353585514 abstract "Objective To study the long-term toxicity of the extract of Lithocarpus litseifolius in rats by repeated oral administration.Methods Daily doses of the extract at 2.0 g/kg,1.0 g/kg,and 0.5 g/kg for 25 weeks were used for high,mid,and low dose group(50 rats each),respectively.Examinations including 16 haematologicalindexes,15 biochemical indexes,and 29 organs(histopathology) were performed at interim administration,withdrawal and 2 weeks after the time,respectively.Results During the administration of glucose in treated group was significantly lower than that in control group(P 0.05) .The liver function indexes in high dose group were significantly higher than those in control group(AST and ALT activities),and their liver cells degenerated.No changes were found in other dose groups.Conclusion Oral administration of the extract of Lithocarpus litseifolius could lower the blood glucose level.Repeated administration of this extract could lead to reversible damage to the liver function." @default.
- W2353585514 created "2016-06-24" @default.
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- W2353585514 date "2010-01-01" @default.
- W2353585514 modified "2023-10-02" @default.
- W2353585514 title "Studies on Long-term Toxicity of the Extract of Lithocarpus Litseifolius in Rats" @default.
- W2353585514 hasPublicationYear "2010" @default.
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