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- W2353600663 abstract "Objective:To investigate the effect of transforming growth factor beta 1(TGF-β1) on the proliferation of human Tenon's capsule fibroblasts(HTFs)and the effect of decorin on the proliferation of HTFs stimulated by TGF-β1.Methods:(1) HTFs of glaucoma patients were cultured and passaged in DMEM medium supplemented with 10% fetal bovine serum,and then the morphosis and stable biological characteristic were investigated after freezing and resuscitation.(2)The 4rd and 6rd generation of HTFs were incubated with various concentrations of TGF-β1(0.01,0.1,1,5,10ng/mL) for 48 hours.The effects of TGF-β1 on the proliferation of HTFs was evaluated by MTT colorimetry.(3) HTFs were treated with 5 ng/mL TGF-β1 and various concentration of decorin(0.01,0.1,1,2,5 μg/mL) for 48 hours in order to observe proliferation of Tenon's fibroblasts by MTT colorimetry.Results:(1) The Tenon's fibroblasts were successfully cultured.It had normal morphosis and stable biological characteristic after freezing and resuscitation.(2)Treatment of the cells with 1～10ng/mL TGF-β1 increased the proliferation of the Tenon's fibroblasts.(3) 2～5μg/mL decorin suppressed the proliferation of the Tenon's fibroblasts stimulated by TGF-β1.Conclusion:TGF-β1 may increase the proliferation of the Tenon's fibroblasts.Decorin could reduce the proliferation of the Tenon's fibroblasts stimulated by TGF-β1.Decorin could bind to TGF-β receptor and interfere in signal transmission,and inhibit the scarring after glaucoma filtering surgery." @default.
- W2353600663 created "2016-06-24" @default.
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- W2353600663 date "2008-01-01" @default.
- W2353600663 modified "2023-09-27" @default.
- W2353600663 title "Effect of Decorin on Proliferation of Tenon's Capsule Fibroblasts Stimulated by TGF-β1" @default.
- W2353600663 hasPublicationYear "2008" @default.
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