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- W2353640179 abstract "Objective To study the immune response in vivo induced by dendritic cells(DC) pulsed with tumor extract inhibits the growth of implanted tumor and rejects the challenge of tumor cells in nude mice.Methods Isolated and purified DC from colon carcinoma patient by combination of granulocyte /macrophage colony stimulating factor and interleukin 4; extracted tumor associated antigen from human colon carcinoma cell line LOVO cells;initiated the T lymphocyte with DC pulsed by the TAA to produce cytotoxic T lymphocyte(CTL);tested the cytotoxic effect of CTL on LOVO cells;implanted the CTL to nudes to inhibit the growth of implanted tumor and to protect the nudes against further challenge of LOVO cells.Results The CTL induced by DC pulsed with TAA from LOVO cells can protect the nudes against the challenge of LOVO cells (protection group,10%,contrast group,100%, P 0 001) and inhibit the growth of implanted tumor in nudes(contrast group 873±19 mm 2,therapy group 569±17 mm 2,re therapy group 361±26 mm 2, P 0 05 and P 0 01).Conclusions The immune response induced by DC not only inhibits the growth of implanted tumor,but also protects against the challenge of LOVO cells in nudes.The results suggest,as a new concept of anti tumor vaccine,DC pulsed by TAA may play an important role in treating and preventing tumor.$$$$" @default.
- W2353640179 created "2016-06-24" @default.
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- W2353640179 date "1999-01-01" @default.
- W2353640179 modified "2023-09-27" @default.
- W2353640179 title "IMMUNE RESPONSE INDUCED BY DENDRITE CELLS PULSED WITH TUMOR EXTRACTS INHIBITS IN VIVO GROWTH OF IMPLANTED TUMOR AND REJECTS CHALLENGE OF TUMOR CELLS IN NUDE MICE" @default.
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