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- W2353643038 abstract "Objective To analyze and evaluate effectiveness of immunization with hepatitis B (HB) vaccine combined with HB immunoglobulin (HBIG) to block its mother-to-child transmission and factors influencing it in Dongcheng district, Beijing, and explore scientific and effective methods to block it to provide scientific evidence for formulating measures to prevent mother-to-child transmission of HB. Methods A cross-sectional study was carried out to investigate HB immunization status of children born to mothers with positive hepatitis B surface antigen (HBsAg), HB infection in mothers, their delivery mode and feeding pattern for their babies and other information. Serum indicators of HB infection and its protective antibodies were tested to evaluate effectiveness of HB vaccination to block mother-to-child transmission and analyze varied factors influencing it.Results In total, 464 children born to mothers with positive HBsAg were investigated in the study, with prevalence of HB infection 5.59 percent and protective efficacy of HB vaccine 93.42 percent. HB infection rate was 24.00 percent and 3.37 percent, respectively after immunization with plasma-derived HB vaccine and genetic engineering (recombinant yeast) HB vaccine. There was significant diference in HB infection rate between children immunized with varied HB vaccine (χ2=35.965, P=0.000). Conclusion Significant effectiveness of HB vaccination combined with HBIG to block mother-to-child transmission has been achieved in Dongcheng district, Beijing. HB infection rate in children born to mothers with positive HBsAg has reduced to relatively lower level. Proitective efficiacy of HB vaccine has increased significantly after introduction of genetic engineering HB vaccine instead of plasma-derived one. Effetiveness of HB vaccine combined with HBIG is not so significant. HB infection status in mothers is an important factor to block mother-to-child transmission. Effectiveness of blocking for single-positive mother-to-child transmission is better than that in dual-positive mothers. Relatively higher conversion rate of HB antibody and antibody titer have been kept in children born to mothers with positive HBsAg in Dongcheng district, Beijing." @default.
- W2353643038 created "2016-06-24" @default.
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- W2353643038 date "2011-01-01" @default.
- W2353643038 modified "2023-09-23" @default.
- W2353643038 title "Evaluation of effectiveness of immunization with hepatitis B vaccine combined with hepatitis B immunoglobulin to block mother-to-child transmission in Dongcheng district of Beijing" @default.
- W2353643038 hasPublicationYear "2011" @default.
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