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- W2353643500 abstract "Objective To investigate the changes of blood flow of superior mesenteric artery, hepatic artery,portal vein and hepatic arterial buffer response(HABR).Methods Twenty-four pigs weighing 21—35 kg were divided into the endotoxemia group(n=12)and control group(n=12). The animals in the endotoxemia group received continuous intravenous infusion of E.coli endotoxin and those in the control group received that of normal saline.The pulmonary arterial wedge pressure, cardiac output,superior mesenteric arterial flow,hepatic arterial flow and portal venous flow were re- corded via Swan-Ganz catheter and ultrasound transit time flow probe.Results During the infusion of endotoxin,the heart rate significantly increased and CO elevated at the 1st h(P≤0.05)and CO, MAP decreased at the 6th,and 8th h as compared with the control group(P≤0.01).In the endotox- emia group,Qha decrease from(0.054±0.03)ml/(kg·min)to(0.01±0.01)ml/(kg·min)(P≤ 0.01),Qpv decreased from(0.26±0.06)ml/(kg·min)to(0.18±0.09)ml/(kg·min)(P≤0.05), Qmsa decreased from(0.15±0.03)ml/(kg·min)to(0.05±0.04)ml/(kg·min)(P≤0.01)and △Qha/△Qpv decreased from(0.16±0.12)to(0.04±0.04)(P≤0.01).There were no significant changes in these parameters in the control group.Conclusions During the continuous infusion of en- dotoxin,hemodynamics changes from hyperdynamic state to hypodynamic one.Meanwhile,the splanchnic blood flow is in low state.The decreased HABR losses the function of maintaining the liver blood flow." @default.
- W2353643500 created "2016-06-24" @default.
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- W2353643500 date "2006-01-01" @default.
- W2353643500 modified "2023-09-28" @default.
- W2353643500 title "Effects of endotoxemia on splanchnic blood flow" @default.
- W2353643500 hasPublicationYear "2006" @default.
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