Matches in SemOpenAlex for { <https://semopenalex.org/work/W2353647528> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2353647528 abstract "Objective To explore the relationship of progressive course and morphologic changes in spontaneously diabetic Goto-Kakizaki rats.Methods Twenty Goto-Kakizaki diabetes prone rats(GK group)and 20 Wistar rats(control group) were enrolled for observation.Body weight,fasting blood glucose,fasting serium insulin,serium triglyceride,cholesterol and OGTT were observed at beginning and after 12 and 24 weeks.The blood samples were collected from the heart.Histological section of their pancreas and myocardium were made and stained by HE.Results The spontaneously diabetic Goto-Kakizaki prone rats had hyperglycemia,hyperlipidemia,hyperinsulinemia,polyuria,polydipsia,polyphagia and also lower body weight.In diabetic rats,serum triglyceride,cholesterol,fasting glucose,fasting insulin markedly increased as compared with those of the control group.HOMA-IR also increased as compared with that of the control group.In GK rats,pancreatic islets obviously increased in number at beginning and later decreased in number and its morphological features became distorted at later stages.In sections of diabetic group at later stages,the striation of myocardial muscles became unclear,striated muscles were deficient in darity and fibrous layer arrangement was slightly distorted,with cardiac myocytolysis and interstitial fibrosis.Conclusion The spontaneously diabetic non-obese Goto-Kakizaki rat exhibits hyperglycemia,hyperlidemia,insulin resistance,poor glucoseinduced insulin secretion,mild diabetic cardiomyopathy and non-obesity,which makes it as a suitable model for studying type 2 diabetes mellitus." @default.
- W2353647528 created "2016-06-24" @default.
- W2353647528 creator A5066713535 @default.
- W2353647528 date "2007-01-01" @default.
- W2353647528 modified "2023-09-25" @default.
- W2353647528 title "Relationship of progressive course and morphologic changes in spontaneously diabetic Goto-Kakizaki rats" @default.
- W2353647528 hasPublicationYear "2007" @default.
- W2353647528 type Work @default.
- W2353647528 sameAs 2353647528 @default.
- W2353647528 citedByCount "0" @default.
- W2353647528 crossrefType "journal-article" @default.
- W2353647528 hasAuthorship W2353647528A5066713535 @default.
- W2353647528 hasConcept C126322002 @default.
- W2353647528 hasConcept C134018914 @default.
- W2353647528 hasConcept C2776553924 @default.
- W2353647528 hasConcept C2777391703 @default.
- W2353647528 hasConcept C2777705978 @default.
- W2353647528 hasConcept C2778163477 @default.
- W2353647528 hasConcept C2778198053 @default.
- W2353647528 hasConcept C2778797674 @default.
- W2353647528 hasConcept C2778913445 @default.
- W2353647528 hasConcept C2779306644 @default.
- W2353647528 hasConcept C2779624480 @default.
- W2353647528 hasConcept C2780180277 @default.
- W2353647528 hasConcept C2780988686 @default.
- W2353647528 hasConcept C2781214132 @default.
- W2353647528 hasConcept C555293320 @default.
- W2353647528 hasConcept C71924100 @default.
- W2353647528 hasConceptScore W2353647528C126322002 @default.
- W2353647528 hasConceptScore W2353647528C134018914 @default.
- W2353647528 hasConceptScore W2353647528C2776553924 @default.
- W2353647528 hasConceptScore W2353647528C2777391703 @default.
- W2353647528 hasConceptScore W2353647528C2777705978 @default.
- W2353647528 hasConceptScore W2353647528C2778163477 @default.
- W2353647528 hasConceptScore W2353647528C2778198053 @default.
- W2353647528 hasConceptScore W2353647528C2778797674 @default.
- W2353647528 hasConceptScore W2353647528C2778913445 @default.
- W2353647528 hasConceptScore W2353647528C2779306644 @default.
- W2353647528 hasConceptScore W2353647528C2779624480 @default.
- W2353647528 hasConceptScore W2353647528C2780180277 @default.
- W2353647528 hasConceptScore W2353647528C2780988686 @default.
- W2353647528 hasConceptScore W2353647528C2781214132 @default.
- W2353647528 hasConceptScore W2353647528C555293320 @default.
- W2353647528 hasConceptScore W2353647528C71924100 @default.
- W2353647528 hasLocation W23536475281 @default.
- W2353647528 hasOpenAccess W2353647528 @default.
- W2353647528 hasPrimaryLocation W23536475281 @default.
- W2353647528 hasRelatedWork W1677212166 @default.
- W2353647528 hasRelatedWork W1987709895 @default.
- W2353647528 hasRelatedWork W1992420001 @default.
- W2353647528 hasRelatedWork W2014097708 @default.
- W2353647528 hasRelatedWork W2016449378 @default.
- W2353647528 hasRelatedWork W2034921827 @default.
- W2353647528 hasRelatedWork W2081341694 @default.
- W2353647528 hasRelatedWork W2081543645 @default.
- W2353647528 hasRelatedWork W2088943831 @default.
- W2353647528 hasRelatedWork W2093418092 @default.
- W2353647528 hasRelatedWork W2122425092 @default.
- W2353647528 hasRelatedWork W2136520057 @default.
- W2353647528 hasRelatedWork W2226565899 @default.
- W2353647528 hasRelatedWork W2318286137 @default.
- W2353647528 hasRelatedWork W2383613041 @default.
- W2353647528 hasRelatedWork W2388278809 @default.
- W2353647528 hasRelatedWork W2392254354 @default.
- W2353647528 hasRelatedWork W2411057518 @default.
- W2353647528 hasRelatedWork W2417809741 @default.
- W2353647528 hasRelatedWork W2978991355 @default.
- W2353647528 isParatext "false" @default.
- W2353647528 isRetracted "false" @default.
- W2353647528 magId "2353647528" @default.
- W2353647528 workType "article" @default.