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- W2353651281 abstract "Objective To assess the roles of apoptosis and expression of the related genes in lacrimal glandular destruction of vitamin A deficient rabbit with experimental xerophthalmia.Methods Six rabbits were given a casein base vitamin A deficient diet for six months and then we got experimental xerophthalmia models. Small pieces of palpebral lobes of lacrimal glands were obtained from the models and 6 normal controls. They had been investigated by the in situ end labeling and immunohistochemical staining to detect the apoptotic cells and the expression of Fas, FasL, Bax and bcl 2.Results The numbers of epithelial apoptotic cells in lacrimal glands of xerophthalmia models and normal rabbits were 18.17±5.33 and 3.56± 1.18 every high view. The former was significantly higher than the later( P 0.001).Xerophthalmia models epithelial cells showed increased expression of Fas, FasL, Bax( 416.33 ± 112.09 , 458.67 ± 120.52 and 328.74 ± 89.08 every thousand cells)and decreased expression of bcl 2 (113.37±72.45 every thousand cells) than the normal (98.83±51.23,126.88±54.09, 87.75 ±43.33 and 396.67±98.73 every thousand cells), P 0.001. There was significant positive correlation between the number of apoptotic cells and that of the cells expressing Fas, FasL, Bax ( r=0.86,0.91,0.88;P 0.01) and respectively negative correlation between apoptotic cells and bcl 2( r=-0.73, P 0.05).Conclusion The apoptosis of the epithelial cells in the lacrimal gland may be one of the mechanisms leading to the glandular destruction found in xerophthalmia. The expression of Fas, FasL and Bax may promote apoptosis, respectively, bcl 2 may inhibit it." @default.
- W2353651281 created "2016-06-24" @default.
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- W2353651281 date "2003-01-01" @default.
- W2353651281 modified "2023-09-25" @default.
- W2353651281 title "Apoptosis and related gene expression in vitamin A deficient rabbit lacrimal gland with experimental xerophthalmia" @default.
- W2353651281 hasPublicationYear "2003" @default.
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