Matches in SemOpenAlex for { <https://semopenalex.org/work/W2353662227> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2353662227 abstract "Yunaconitine (YAc) is an alkaloid isolated from Aconi-tum hemsleyanum Pritz, var. circina-tum W. T. Tang and Aconitum ge-niculatum Flet.et Laue.var. unguicu-latum W. T. Wang. It is not only highly toxic, but also highly active biologically. Recently, anti-inflammatory, analgesic and antipyretic effects were found at very low dosages. In this paper immunomodula-ting actions of YAc were reported.Split heart tissue of new born C57 /BL mice were transplanted in adult male ICR mice ear pinna. ECG was followed every day to judge the survival time of allografts.YAc 50μg/ (kg·d)ip from the second day after heart transplantation markedly prolonged the survival time of allografts and was comparable to the well-known immunosuppressor predniso-lone. When they were given from the seventh day after operation, no marked effect of both drugs wasobserved. A tendency of inhibited delayed type hypersensitivity to EAE antigen was observed in EAE rats administered with YAc 5 and 10 μg/kg ip.YAc ip 20μg/kg×4 d showed no definite inhibition on serum hemoly-sin and IgG levels, 50 μg/kg×3 d suppressed the spleen PFC counts of SRBC challenged C57/BL mice. It is noticed that YAc increased serum total complement as well as the phag-ocytic activity of reticuloendothelial system in mice. These effects are considered to be beneficial in the clearance of pathogenic antigens, and may be the immunopharmacological basis of antiinflammatory actions of YAc." @default.
- W2353662227 created "2016-06-24" @default.
- W2353662227 creator A5022717704 @default.
- W2353662227 date "1987-01-01" @default.
- W2353662227 modified "2023-09-23" @default.
- W2353662227 title "Immunomodulating actions of yunaconitine" @default.
- W2353662227 hasPublicationYear "1987" @default.
- W2353662227 type Work @default.
- W2353662227 sameAs 2353662227 @default.
- W2353662227 citedByCount "0" @default.
- W2353662227 crossrefType "journal-article" @default.
- W2353662227 hasAuthorship W2353662227A5022717704 @default.
- W2353662227 hasConcept C126322002 @default.
- W2353662227 hasConcept C147483822 @default.
- W2353662227 hasConcept C162156334 @default.
- W2353662227 hasConcept C19702531 @default.
- W2353662227 hasConcept C203014093 @default.
- W2353662227 hasConcept C2777667214 @default.
- W2353662227 hasConcept C2777928079 @default.
- W2353662227 hasConcept C2779252780 @default.
- W2353662227 hasConcept C2780820201 @default.
- W2353662227 hasConcept C2780931953 @default.
- W2353662227 hasConcept C2911091166 @default.
- W2353662227 hasConcept C59822182 @default.
- W2353662227 hasConcept C71924100 @default.
- W2353662227 hasConcept C86803240 @default.
- W2353662227 hasConcept C98274493 @default.
- W2353662227 hasConceptScore W2353662227C126322002 @default.
- W2353662227 hasConceptScore W2353662227C147483822 @default.
- W2353662227 hasConceptScore W2353662227C162156334 @default.
- W2353662227 hasConceptScore W2353662227C19702531 @default.
- W2353662227 hasConceptScore W2353662227C203014093 @default.
- W2353662227 hasConceptScore W2353662227C2777667214 @default.
- W2353662227 hasConceptScore W2353662227C2777928079 @default.
- W2353662227 hasConceptScore W2353662227C2779252780 @default.
- W2353662227 hasConceptScore W2353662227C2780820201 @default.
- W2353662227 hasConceptScore W2353662227C2780931953 @default.
- W2353662227 hasConceptScore W2353662227C2911091166 @default.
- W2353662227 hasConceptScore W2353662227C59822182 @default.
- W2353662227 hasConceptScore W2353662227C71924100 @default.
- W2353662227 hasConceptScore W2353662227C86803240 @default.
- W2353662227 hasConceptScore W2353662227C98274493 @default.
- W2353662227 hasLocation W23536622271 @default.
- W2353662227 hasOpenAccess W2353662227 @default.
- W2353662227 hasPrimaryLocation W23536622271 @default.
- W2353662227 hasRelatedWork W1572053788 @default.
- W2353662227 hasRelatedWork W1598229557 @default.
- W2353662227 hasRelatedWork W1766355117 @default.
- W2353662227 hasRelatedWork W1918515157 @default.
- W2353662227 hasRelatedWork W1949804417 @default.
- W2353662227 hasRelatedWork W1982012081 @default.
- W2353662227 hasRelatedWork W2003929165 @default.
- W2353662227 hasRelatedWork W2004809656 @default.
- W2353662227 hasRelatedWork W2040620043 @default.
- W2353662227 hasRelatedWork W2067702376 @default.
- W2353662227 hasRelatedWork W2071369362 @default.
- W2353662227 hasRelatedWork W2120867199 @default.
- W2353662227 hasRelatedWork W2151510773 @default.
- W2353662227 hasRelatedWork W2171075468 @default.
- W2353662227 hasRelatedWork W2199300543 @default.
- W2353662227 hasRelatedWork W2331970383 @default.
- W2353662227 hasRelatedWork W2378205037 @default.
- W2353662227 hasRelatedWork W2410035561 @default.
- W2353662227 hasRelatedWork W2439847096 @default.
- W2353662227 hasRelatedWork W3031327079 @default.
- W2353662227 isParatext "false" @default.
- W2353662227 isRetracted "false" @default.
- W2353662227 magId "2353662227" @default.
- W2353662227 workType "article" @default.