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- W2353669583 abstract "OBJECTIVE:To investigate protective effect of sodium aescinate on acute lung injury(ALI)model rats.METHODS:45 SD rats were randomly divided into normal control group(constant volume of normal saline),model group(constant volume of normal saline)and sodium aescinate group(5 mg/kg).ALI model was made by intravenous injection of oleic acid(0.1 ml/ kg).30 min after modeling,they were given relevant medicines via tail vein.The histological section of lung tissue was observed under light microscope.The lung wet and dry weight were determined to calculate lung wet/dry weight ratio(W/D);TNF-α concentration and expression of AQP1 were determined by ELISA assay and Western blot,respectively.RESULTS:Compared with normal control group,the effusion of inflammatory cell in the alveolar space increased in model group,while W/D,TNF-α concentration and protein expression of AQP1 increased;there was statistical significance(P0.05).Compared with model group,pneumonedema of rats was improved significantly in sodium aescinate group,while W/D,TNF-α concentration and protein expression of AQP1 decreased;there was statistical significance(P0.05).CONCLUSIONS:Sodium aescinate may alleviate oleic acid-induced ALI in rats,the mechanism of which may be associated with the down-regulation of W/D,TNF-α concentration and protein expression of AQP1." @default.
- W2353669583 created "2016-06-24" @default.
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- W2353669583 date "2014-01-01" @default.
- W2353669583 modified "2023-09-24" @default.
- W2353669583 title "Protective Effect of Sodium Aescinate on Acute Lung Injury Model Rats" @default.
- W2353669583 hasPublicationYear "2014" @default.
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