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- W2353673907 abstract "Varicella-zoster virus(VZV)is a ubiquitous human alphaherpesvirus that causes varicella(chickenpox)during primary infection,can establish latency in sensory ganglia,and may reactivate to cause herpes zoster(shingles).Though VZV possesses the smallest genome among all human herpesviruses,little was known about its gene function and the attenuation mechanisms of VZV vaccine due to the difficulty of generating mutants to investigate gene function and the long period of time needed to establish pure clones using conventional techniques with mammalian cells.Recently,a completely new approach for full-length infectious clones of VZV based on bacterial artificial chromosomes(BACs)has been developed.This technique allows the maintenance,propagation and genetic modification of the viral genome as a BAC plasmid in E.coli,thus making the procedures fast,safe and effectivein prokaryotic cells.This technique also makes it possible for the reconstitution of viral progeny or mutants by transfection of the BAC plasmid into eukaryotic cells,thereby facilitating the an alysis of viral gene functions in the context of genome.The VZV BAC system also was useful as a vector for construction of recombinant live vaccines." @default.
- W2353673907 created "2016-06-24" @default.
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- W2353673907 date "2010-01-01" @default.
- W2353673907 modified "2023-09-28" @default.
- W2353673907 title "Infectious Cloning Approach and Application for Varicella-Zoster Virus Based on Bacterial Artificial Chromosomes" @default.
- W2353673907 hasPublicationYear "2010" @default.
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