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- W2353678473 abstract "Objective: To study the effect of the dendritic cells(DCs) subsets infection on CCL-11 and IL-13Rα2 expression and eosinophils infiltration in OVA-induced lung tissue cells by adoptive transfer of DC subsets from mice infected with Schistosoma japonicum.Methods: DC subsets from mice infected with S.japonicun were respectively isolated and purified using CD8α and CD11c microbeads.Twenty four BALB/c mice were randomly divided into four groups.Group normal served as the control.Group OVA was the asthma group.Each mouse in group SJCD8α+DC/OVA was injected with CD8α+DC from mice infected S.japonicun,while each mouse in group SJCD8α-DC/OVA was injected with CD8α-DC.One hour after adoptive transfer,All but group normal were sensitized and challenged with ovalbumin to induce asthma.Mice were sacrificed after four weeks and their lungs were removed for HE staining and immunohistochemistry staining,inflammatory changes were observed,and levels of CCL-11 and IL-13Rα2 expression were detected in lung tissue.Results:HE staining indicated that group Normal had no inflammation and SJCD8α-DC/OVA had slight inflammation.The groups SJCD8α+DC/OVA and OVA had serious inflammation and larger number of infiltrating inflammatory cells.In group Nromal,OVA,SJCD8α+DC/OVA and SJCD8α-DC/OVA lung tissue immuohistochemical staining showed that the average opitical density(AOD) of CCL-11 were 0.152 3±0.010 9,1.496 7±0.225 6,1.343 5±0.094 9 and 0.863 4±0.211 4,the positive area of CCL-11 in blood vessels and trachea's percentage of the total area were 0.000 4±0.000 3,0.257 2±0.085 9,0.210 3±0.023 1 and 0.039 2±0.005 4;the AOD of IL-13Rα2 were 0.152 7±0.015 3,0.334 5±0.003 7,0.283 2±0.035 0 and 0.175 5±0.020 1,the percentage of the IL-13Rα2's area of the total area were 0.037 0±0.034 1,0.297 0±0.006 2,0.287 0±0.031 0 and 0.117 1±0.005 0.The difference in percentage and AOD between groups was statistically significant(P0.05).Conclusion: The CD8α-CD11c+DC subset from mice infected with S.japonicun can inhibit the OVA-induced expression of CCL-11 and IL-13Rα2 and there by inhibiting asthma." @default.
- W2353678473 created "2016-06-24" @default.
- W2353678473 creator A5051984818 @default.
- W2353678473 date "2013-01-01" @default.
- W2353678473 modified "2023-09-23" @default.
- W2353678473 title "Effect of adoptive transfer of CD8α~-CD11c~+ dendritic cells from mice infected with Schistosoma japonicum on OVA-induced CCL-11 and IL-13Rα_2" @default.
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