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- W2353685183 abstract "Objective To investigate the expression and significance of MMP-9 and Ki67 for predicting the progression and prognosis of pancreatic cancer. Methods S-P immunohistochemical method was used to detect the expressions of MMP-9 and Ki67 in 100 pancreatic cancer tissue specimens. The relationship between the expressions of MMP-9 and Ki67 and patient age, tumor size, lymph node metastasis, tumor differentiation, clinical stages and prognosis were analyzed. Results There were higher expressions of MMP-9 protein 46%(46/100) and Ki67 protein 53%(53/100) in 100 samples of pancreatic adenocarcinoma. And the expressions of MMP-9 and Ki67 were inversely associated with tumor differentiation, clinical stages, and lymph node metastasis of pancreatic cancer(P 0.05). There were no significant differences in the expressions of MMP-9 and Ki67 between patient age and tumor size. The expressions of MMP-9 and Ki67 were positive correlated(rs =0.405,P0.05). Moreover, the overall survival rates were correlated with patient age, lymph node metastasis, tumor differentiation and the expression of MMP-9, but no correlation with tumor size, clinical stages, and the expression of Ki67. Conclusion The expressions of MMP-9 and Ki67 were associated with pancreatic cancer progression. And the detection of expression of MMP-9 may have practical value in prognosis in patients with pancreatic cancer." @default.
- W2353685183 created "2016-06-24" @default.
- W2353685183 creator A5021570053 @default.
- W2353685183 date "2014-01-01" @default.
- W2353685183 modified "2023-09-28" @default.
- W2353685183 title "The Differential Expression of MMP-9 and Ki67 in Pancreatic Cancer" @default.
- W2353685183 hasPublicationYear "2014" @default.
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