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- W2353687270 abstract "Objective To investigate the protection of neuregulin-1β(NRG-1β) on retinal cells after ischemical reperfusion injury and the effects of NRG-1β on the expression of Bax protein. Methods A model of retinal ischemia reperfusion in rat was made.Thirty-three wistar rats were divided into three groups as normal(three rats),control(15 rats) and experimental(15 rats).An injection of 5 μL of NRG-1β into vitreous cavity of the rats in experimental group was offered,and 5 μL of BSS in the control group.Retinal paraffin sections were stained with TdT-mediated dUTP nick end labeling to examine the apoptosis of retinal cells.The expression of Bax was detected immunohistochemically. Results Apoptotic cells mainly appeared in the inner nuclear and the ganglion cell layers,almost no positive expression was seen in the outer nuclear layer.Compared with the control group,the numbers of apoptotic cells and eressions of Bax in various time points in experimental group were significantly lower(t=2.57-11.97,P0.01). Conclusion NRG-1β shows a significant protection for retina with ischemical reperfusion injury.The inhibition of Bax by NRG-1β may be one of the mechanisms preventing the apoptosis of this kind of retinal cell injury." @default.
- W2353687270 created "2016-06-24" @default.
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- W2353687270 date "2009-01-01" @default.
- W2353687270 modified "2023-09-23" @default.
- W2353687270 title "EFFECTS OF NEUREGULIN-1β ON APOPTOSIS OF RETINAL CELLS AND EXPRESSION OF Bcl-2-ASSOCIATED X PROTEIN IN RATS WITH ISCHEMICAL REPERFUSION INJURY" @default.
- W2353687270 hasPublicationYear "2009" @default.
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