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- W2353744467 abstract "Aim To investigate the effect of xinyue capsule( XYC) on protein expression of ischemic myocardial osteopontin( OPN),tenascin-C( TN-C) and heart function during prophase ventricular remodeling( VR) after acute myocardial infarction( AMI) in rats.Meanwhile,explore the possible mechanism on extracellular matrix( ECM) metabolism.Methods The AMI model was established by ligating the left anterior descending coronary artery of rats to induce myocardial infarction.60 Wistar rats with model establishment were randomly divided into 4 groups,15 rats in each group.They were sham group( the suture was penetrated around the left anterior descending coronary artery,but not tied),model group,valsartan group of which valsartan was given 7.2 mg·kg-1·d-1,XYC group of which XYC was given 162 mg·kg-1·d-1.All of the medicine was given by gavage from the second day after model establishment.Both sham and model group were administered with equivalent distilled water.After continuous intragastric administration of 4 weeks,ultrasonic cardiography was used to examine the morphologic change and heart function.HE staining was used to observe the myocardial pathological change.The protein expression of OPN and TN-C in myocardial tissue was tested semiquantitatively by immunohistochemical method.Myocardium contents of angiotensin Ⅱ( AngⅡ),aldosterone( ALD) and tissue growth factor-β1( TGF-β1) were tested by radioimmunoassay method.Results Compared with model group:① left ventricular end-systole dimension( LVED) reduced significantly and left ventricular ejection fraction( LVEF) increased significantly in PQS group( P 0.05);② both interventricular septum end-diastole thickness( IVSTd) and interventricular septum endsystole thickness( IVSTs) increased significantly in XYC group( P 0.05);③ ischemic myocardium protein expression of OPN decreased significantly in XYC group( P 0.0 1) and TN-C decreased significantly in XYC group( P 0.05);④ myocardial tissue contents of AngⅡ,ALD and TGF-β1 decreased significantly in XYC group( P 0.05,P 0.01).Conclusion XYC can improve the heart function by attenuating the prophase VR of rats after AMI.The possible mechanism of the improvement is that panax quinquefolius saponin( PQS) effective constituent of XYC can regulate ECM metabolism by inhibiting neuroendocrine factors production,alleviating inflammation reaction and reducing ischemic myocardial protein expression of OPN and TN-C." @default.
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- W2353744467 date "2013-01-01" @default.
- W2353744467 modified "2023-09-24" @default.
- W2353744467 title "Effect of Xinyue capsule on protein expression of ischemic myocardial osteopontin and tenascin-C in rats after myocardial infarction" @default.
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