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- W2353757360 abstract "Objective To investigate the effect of β3 adrenergic receptor(AR)agonist and antagonist on matrix metalloproteinases(MMP)-2 and MMP-9 in heart failure rat model and to study the potential relationship between β3 AR and left ventricular remodeling.Methods Ten rats served as control group and 130 rats received isoproterenol to make heart failure model.Heart failure rats were randomly divided into agonist group(n=12),antagonist group(n=10) and heart failure group(n=11).Agonist group and antagonist group received BRL37344 1.65 μg/kg or SR59230A 50 μg/kg through caudal vein for 10 min twice a week dividually.All below were measured at the 4th and 8th week: cardiac function,ratio of LV weight and body weigh(LVW/BW) and collagen volume fraction(CVF),expression of MMP-2 and MMP-9 proteins by the techniques of immuno-histochemistry;the expression levels of MMP-2 and MMP-9 mRNA in myocardium were examined by reverse transcription-polymerase chain reaction(RT-PCR).Results Compared with control group,the cardiac function of heart failure group wasaggravated while the cardiac function of agonist group was further aggravated;these change were significantly attenuated in antagonist group;In comparison with the control group,the expressions of MMP-2 and MMP-9 mRNA and proteins increased with time in heart failure models,and SR59230A treatment decreased the expression(all P0.01).Conclusion β3AR may play a role in left ventricular remodeling by the effect of MMP-2 and MMP-9." @default.
- W2353757360 created "2016-06-24" @default.
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- W2353757360 date "2010-01-01" @default.
- W2353757360 modified "2023-09-27" @default.
- W2353757360 title "Effect of β_3 adrenergic receptor agonist and antagonist on expression of MMP-2 and MMP-9 in heart failure rat" @default.
- W2353757360 hasPublicationYear "2010" @default.
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