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- W2353758107 abstract "Objective To compare the curative effect of ligustrazine phosphate and ligustrazine hydrochloride on focal cerebral ischemia induced by middle cerebral artery occlusion in rats.Methods Forty Sprague-dawley rats were randomly divided into four groups: normal control group,model control group,ligustrazine phosphate group and ligustrazine hydrochloride group.The focal cerebral ischemic model was induced by middle cerebral artery occlusion with intraluminal thread method in rats.After surgery,the rats were treated with different solution 10 mL/kg by intravenous administration.Nervous symptom score was measured at 12 hours after operation.The rats were sacrificed and the brains were removed at 24 hours after operation,then,the cerebral infarct area was calculated by TTC staining and the histopathological examination of brains was detected.Results Compared with the control groups,ligustrazine phosphate and ligustrazine hydrochloride could significantly reduce infarct area and infarct rate,relieve nervous symptom,inhibit neuronal degeneration and neurocyte edema,and the difference wasstatistically significant.However,there was no statistical difference between ligustrazine phosphate group and ligustrazine hydrochloride group.Conclusion The curative effect of ligustrazine phosphate on focal cerebral ischemia is equivalent to that of ligustrazine hydrochloride." @default.
- W2353758107 created "2016-06-24" @default.
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- W2353758107 date "2008-01-01" @default.
- W2353758107 modified "2023-09-24" @default.
- W2353758107 title "Comparative Study on Effect of Ligustrazine Phosphate and Ligustrazine Hydrochloride on Focal Cerebral Ischemic Rats" @default.
- W2353758107 hasPublicationYear "2008" @default.
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