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- W2353761006 abstract "AIM To explore the protective effect of polysaccharide from Yam on the neuron apoptosis indued by hypoxia. METHODS Neural cells in cortical neurous isolated from SD rat embryos were applied to establishing the model for the hypoxic nerve cell damage,and then obtained nerve cells were treated with polysaccharide from Yam of various concentrations. Mitochondria injury was examined by Rhodamine 123 staining in flow cytometry. The mRNA and protein expressions of Caspase-3,Bax,Bcl-2 were identified by RT-PCR and immunocytochemistry. RESULTS The mitochondria injury was significantly inhibited,the levels of caspase-3 and Bax mRNAs and proteins were significantly down-regulated by polysaccharide from Yam,the levels of Bcl-2 mRNA and protein were significantly up-regulated,and the ratio of Bcl-2 / Bax in mRNA and protein were significantly elevated by polysaccharide from Yam( P 0. 05). CONCLUSION Polysaccharide from Yam has an inhibitory effect on apoptosis of neurons caused by hypoxia,due to the decrease in levels of apoptotic genes and proteins and the increase in levels of anti-apoptotic gene and protein in hypoxic neurons." @default.
- W2353761006 created "2016-06-24" @default.
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- W2353761006 date "2013-01-01" @default.
- W2353761006 modified "2023-09-27" @default.
- W2353761006 title "Effect of polysaccharide from Yam against neuron apoptotic induced by hypoxia" @default.
- W2353761006 hasPublicationYear "2013" @default.
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