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- W2353769341 abstract "Objective To explore the roles of calpain in myocardial TNF-α mRNA expression and cardiac dysfunction in septic mice with hyperglycemia. Methods Adult mice were injected by streptozocin (STZ,150 mg /kg,i.p.) to induce hyperglycemia; mice with hyperglycemia one week later or normal mice were injected by lipopolysaccharide (LPS,4 mg/kg,i.p.) to induce sepsis. Myocardial calpain activity and TNF-αmRNA were detected,cardiac function was evaluated by Langendoff perfusion parameter. Results In septic mice,myocardial calpain activity and expression of TNF-αmRNA were increased,which was prevented by calpain inhibitor,calpain inhibitor-Ш and PD150606. Compared with septic mice,septic mice with hyperglycemia showed higher myocardial calpain activity,higher expression of TNF-αmRNA and more deteriorative cardiac dysfunction. Conclusion In septic mice with hyperglycemia,myocardial calpain activity increases,which modulates myocardial TNF-α mRNA expression,the latter may attribute to the more deteriorative cardiac dysfunction." @default.
- W2353769341 created "2016-06-24" @default.
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- W2353769341 date "2009-01-01" @default.
- W2353769341 modified "2023-09-24" @default.
- W2353769341 title "Roles of calpain in myocardial TNF-α mRNA expression and cardiac dysfunction in septic mice with hyperglycemia" @default.
- W2353769341 hasPublicationYear "2009" @default.
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