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- W2353779163 abstract "Objective To investigate the effects of isosorbide dinitrate and meglumine adenosine cyclophosphate on the level of N-terminal pro-brain natriuretic peptide(NT-proBNP) in blood plasma of patients with chronic cardiac insufficiency.Methods A total of 64 patients with chronic cardiac insufficiency,who were hospitalized from May 2009 to November 2010 were divided into 2 groups according to the time order of their admission,i.e.the isosorbide dinitrate group(n=32) and the meglumine adenosine cyclophosphate group(n=32).In addition to routine treatment,the 2 groups were administered isosorbide dinitrate(10-20 mg/d) and meglumine adenosine cyclophosphate(180 mg/d) respectively with mini-pumps.Then,the levels of NT-proBNP in blood plasma were measured both before treatment and 1 week after treatment.Results One week after treatment,the levels of NT-proBNP in blood plasma for both groups all reduced significantly,when compared with those before treatment(P0.01).And the levels of NT-proBNP pre and post treatment and also 1 week after treatment were all not statistically significant for the 2 groups(P0.05).Conclusion Routine treatment coupled with isosorbide dinitrate or meglumine adenosine cyclophosphate could significantly reduce the levels of NT-proBNP in blood plasma in patients with chronic cardiac insufficiency and no statistical differences could be seen in the therapeutic effect of the two drugs(P0.05)." @default.
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- W2353779163 date "2012-01-01" @default.
- W2353779163 modified "2023-09-25" @default.
- W2353779163 title "Effects of isosorbide dinitrate and meglumine adenosine cyclophosphate on the level of N-terminal pro-brain natriuretic peptide in blood plasma of patients with chronic cardiac insufficiency" @default.
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