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- W2353803485 abstract "[Objective] To explore the effect of interaction between organochlorine pesticides residues and CYP1A1 Msp Ⅰ,GSTM1,GSTT1 genetic polymorphisms on female breast cancer. [Methods] 1︰1 matched case-control study method was adopted. 70 newly diagnosed female breast cancer patients and 70 controls from September 2006 to October 2007 were selected as cases. Serum of cases and controls were collected,and the concentrations of DDT and HCH were measured by gas chromatography(GC) according to GB /T5009.19-2003. Genetic polymorphisms of CYP1A1 Msp Ⅰ,GSTM and GSTT1 were analyzed by polymerase chain reaction(PCR) . [Results] The results showed that interaction existed in genetic polymorphisms of CYP1A1 Msp Ⅰ and HCH /DDT residues,and interaction indexes(γ) value were 1.558 and 8.491;interaction existed in genetic polymorphisms of GSTT1 and DDT residues,and interaction indexes(γ) value was 1.726. [Conclusion] CYP1A1 Msp Ⅰ heterozygote and GSTT1 null genetype may amplify the effect of organochlorine pesticides." @default.
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- W2353803485 date "2010-01-01" @default.
- W2353803485 modified "2023-09-27" @default.
- W2353803485 title "INTERACTION BETWEEN ORGANOCHLORINES PESTICIDES RESIDUES AND CYP1A1 MSP I,GSTM1,GSTT1 GENETIC POLYMORPHISMS ON THE EFFECT OF FEMALE BREAST CANCER OCCURRENCE" @default.
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