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- W2353808506 abstract "Aim:To investigate the injury effects of dopaminergic neurons induced by LPS in rat mesencephalic neuron-glia cultures.Methods:Rat mesencephalic neuron-glia cultures were obtained from timed pregnant SD-rats on embryonic 14 d.Ⅰ:The mesencephalic neuron-glia cultures were categorized into five groups:control and LPS(0.01,0.10,1.00,and 10.00 mg/L)group.On the 7th day of culture,different concentrations of LPS were incubated for 72 h.Dopaminergic neurons were identified and counted by using tyrosine hydroxylase(TH)immunochemistry.Ⅱ:The mesencephalic neuron-glia cultures were categorized into two groups:control and LPS group(0.1 mg/L).On the 7th day of culture,0.1 mg/L LPS was incubated for different times(8,24,and 72 h).After administration supernatants were collected,IL-6 levels were detected by using ELISA.Dopaminergic neurons and actived microglias were identified and counted by using TH and ionized calcium binding adaptor molecule 1(Iba1)immunochemistry.Results:The number of TH positive cells reduced significantly with shorter cell processes showing bead-like.The IL-6 levels in 0.1 mg/L LPS-treated groups of 8,24 and 72 h after administration,increased significantly(t was 15.787,16.712 and 15.910,P0.001).The number of actived microglias were(40.0±6.1),(76.0±3.4),and(69.0±5.2),respectively(F=387.820,P0.001).The number of dopaminergic neurons were(18.0±5.3)and(10.0±3.2)in 0.1 mg/L LPS-treated groups of 24 and 72 h after administration,respectively(F=94.840,P0.001).Conclusion:Microglias may play an important role in injury effects of dopaminergic neurons,activated by LPS to release IL-6." @default.
- W2353808506 created "2016-06-24" @default.
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- W2353808506 date "2011-01-01" @default.
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- W2353808506 title "Injury effects of LPS on mesencephalic neuron-glia cultures of rats" @default.
- W2353808506 hasPublicationYear "2011" @default.
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