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- W2353818350 abstract "Objective To investigate the sensitivity of 5 kinds of chemotherapeutic drugs on human colorectal cancer in vivo.Methods Xenografts in nude mice were set up by tumor tissues from 9 patients with colorectal cancer and nude mice were divided into 6 groups randomly,receiving saline(control group),5-fluorouracil(5-FU group),doxorubicin(ADM group),mitomycin(MMC group),oxaliplatin(LOHP group),and irinotecan(CPT-11 group),respectively.The inhibitive rates(IR) of xenografts in 5 groups for each patient were calculated.Results The lowest and highest IR of 5 groups were 23.6% and 54.9% in 5-FU group,23.7% and 69.5% in LOPH group,23.6% and 82.6% in CPT-11 group,24.1% and 48.1% in MMC group,5.8% and 20.7% in ADM group,respectively.The IR exceeded 40.0% in 7 patients of LOHP group,6 patients of CPT-11 group,4 patients of 5-FU group,and 1 patient of MMC group,respectively.Of 9 patients,the IR exceeded 40.0% to 3 kinds of drugs in 3 patients,to 2 kinds of drugs in 4 patients,the IR didn't exceed 30.0% to 4 kinds of drug(IR was 82.6% to CPT-11) in 1 patient,and the IR didn't exceed 31.0% to all 5 kinds of drugs in 1 patient.There were statistical differences on the IR of 5 kinds of drugs(H=24.061 2,P=0.000 1).IR of ADM group was statistical lower than 5-FU group,MMC group,LOHP group,and CPT-11 group(P0.05),but there were no statistical differences between 5-FU group,MMC group,LOHP group,and CPT-11 group(P0.05).Conclusions The xenografts from same patient have different sensitivity to different chemotherapy drugs,and the same chemotherapy drug corresponds to different IR in different patients.The IR of LOHP and CPT-11 are the highest,following by 5-FU and MMC." @default.
- W2353818350 created "2016-06-24" @default.
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- W2353818350 date "2013-01-01" @default.
- W2353818350 modified "2023-09-24" @default.
- W2353818350 title "Sensitivity Test of Chemotherapy on Human Colorectal Cancer in Vivo" @default.
- W2353818350 hasPublicationYear "2013" @default.
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