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- W2353819365 abstract "Objective To investigate the relationship between different molecular subtypes and the therapeutic effect and prognosis of dose dense docetaxel neoadjuvant chemotherapy in breast cancer.Methods 82 breast cancer patients admitted to our hospital from March 2007 to March 2010 were given four cycles of docetaxel chemotherapy(75 mg/m2,with two weeks as a cycle),followed by surgical operation.After operation,the patients were given four cycles of EC chemotherapy(with EPI 75 mg/m2,CTX 600 mg/m2 and two weeks as a cycle).Immunohistochemical studies and fluorescence in-situ hybridization were performed to detect the expression of estrogen receptor(ER),progesterone receptor(PR),Her-2 and Ki67 of breast cancer before treatment.The patients were classified into 4 subtypes:luminal A,luminal B,Her-2+ and triple negative.The therapeutic effect and prognosis of the four subtypes after dose dense docetaxel neoadjuvant chemotherapy were analyzed.Results Of the total 82 patients,the overall response rate(RR) was 89.0%(73/82),including 17 cases of complete response(CR),56 cases of partial response(PR),9 cases of stable disease(SD) and no progression of disease(PD).FISH were performed to detect 11 cases of IHC scores of 2+.There were 5 cases for the overexpression of Her-2.According to the results of immunohistochemical studies and FISH method on the expression of ER,PR,Her-2 and Ki67,there were 39 cases(47.6%) of Luminal A,19 cases(23.2%) of Luminal B,11 cases(13.4%) of Her-2+ and 13 cases(15.9%) of triple negative.The age,tumor size,lymph node metastasis,histological type and surgical style among breast cancer patients with different molecular subtypes showed no statistically significant differences(P0.05).The RR of luminal A,luminal B,Her-2+ and triple negative were 84.6%(33/39),84.2%(16/19),100.0%(11/11) and 100.0%(13/13) respectively,and the difference was not statistically significant(χ2=4.185,P=0.242).Until June 2012,the three-year disease-free survival(DFS) and overall survival(OS) of the 82 patients were 85% and 88% respectively,and the differences between the four subtypes were statistically significant(χ2=9.584 and 9.414,P0.05).The three-year DFS and OS of Luminal A subtype showed statistically significant differences compared with Her-2+ and triple negative(P0.05).Conclusion The therapeutic effect of 75 mg/m2 one-drug dose dense docetaxe neoadjuvant chemotherapy on luminal A,luminal B,Her-2+ and triple negative are similar.However,the prognosis of luminal A was better than those of the Her-2+ and triple negative." @default.
- W2353819365 created "2016-06-24" @default.
- W2353819365 creator A5026706383 @default.
- W2353819365 date "2012-01-01" @default.
- W2353819365 modified "2023-09-23" @default.
- W2353819365 title "Relationship of Molecular Subtypes and Therapeutic Effect and Prognosis of Dose Dense Docetaxel Neoadjuvant Chemotherapy in Breast Cancer" @default.
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