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- W2353832904 abstract "To observe the effect of salvia miltiorrhiza on MMP-9 and MVD in liver cancer model of DEN rat,and study the influence of salvia miltiorrhiza on hematogenous metastasis of liver cancer.Methods: 40 Wistar rats were randomly divided into normal group,model group,prevention group and the treatment group.In addition to normal group,the other four groups were induced into liver cancer models by intermittent small doses of DEN.From the 15th week normal group and model group were fed up with normal saline as 5ml/kg.Prevention group from the first week and treatment group from the 15th week were fed up with 0.2g/ml Salvia Decoction as 5mL/kg by intragastric administration.Till the 20th week all were put to death.After drawing the experimental materials,the expression of MMP-9 and CD34 were detected with immunohistochemistry,and the concentration of MMP-9 were done with the enzyme-linked immunosorbent assay.Results: There were significant differences between the groups on the concentration of MMP-9,the expression of MMP-9 and MVD.Especially among model group,prevention group and treatment group,extremely significant differences showed.Conclusion: Salvia miltiorrhiza can inhibit the hematogenous metastasis of liver tumor cells by inhibiting MMP-9 formation and inhibiting the matrix degradation to reduce MVD." @default.
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- W2353832904 date "2011-01-01" @default.
- W2353832904 modified "2023-09-23" @default.
- W2353832904 title "The Effect of Salvia Miltiorrhiza on MMP-9 and MVD in Liver Cancer Model of Rat" @default.
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