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- W2353846985 abstract "[Objective] To evaluate the antimutagenic potential of soy oligopeptide by TK gene mutation tests.[Methods] The TK6 human lymphoid cells were treated in three antimutagenic experimental protocols,i.e.pre-,post-and simulta-neous treatments,with soy oligopeptide at the concentrations of 1.25,2.50,5.00,10.0 mg /ml and 5μg /ml of methyl methanesulfonate(MMS).Determination of mutant frequency of TK locus were performed using the microcell method.[Results] Soy oligopeptide significantly reduced the mutagenicity of MMS in the pre-and simultaneous treatments at all of the con-centrations tested compared with the respective MMS control,and in the post-protocol,significant reductions of the mutant frequency were detected at the concentrations of 5.00,10.0 mg /ml.On the other hand,the mutation index of soy oligopeptide added before MMS treatment was less than that in the post-and simultaneous protocols.[Conclusion] The results suggest that soy oligopeptide has a good role for preventing TK gene mutation induced by MMS,especially in the pre-treatment." @default.
- W2353846985 created "2016-06-24" @default.
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- W2353846985 date "2009-01-01" @default.
- W2353846985 modified "2023-09-27" @default.
- W2353846985 title "DETECTION OF ANTIMUTAGENICITY OF SOY OLIGOPEPTIDE BY TK GENE MUTATION TEST" @default.
- W2353846985 hasPublicationYear "2009" @default.
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