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- W2353860254 abstract "Objective:To detect the change of the number of platelet-derived microparticle(PMP) and the activation ratio of GPⅡb/Ⅲa and CD62P in avascular osteonecrosis of the femoral head(ANFH) before and after treatment with traditional Chinese medicine,and to investigate the function and influence of traditional Chinese medicine on platelet activation in ANFH patients.Methods:The randomized,double-blind,and placebo-controlled study methods were used in 40 ANFH patients,which divided into Bushenhuogu treatment group(group A) and placebo-controlled treatment group(group B),20 patients in each group.Twenty healthy volunteers were taken as controp group(group C).Flow cytometry was used to measure the quantity of PMP and activation ratio of PAC-1 and CD62P,and automatic-biochemical analyzer was used to measure hemorheology index.Results: The quantity of PMP,activation ratio of PAC-1 and CD62P,and the index of hemorheology were significantly different between group A and group B before treatment,but the parameters in the two groups were significant higher than group C(t=4.8,t=10.4,t=12.4,respectively,all P0.001,and t=4.7,t=9.7,t=14.3,respectively,all P0.001).These parameters were significantly decreased in group A(t=4.5,t=13.0,t=11.2,respectively,all P0.001),which were obviously different compared to those in group B after 24 weeks treatment.Correlation analysis showed that there was a signi?cant positive correlation between the quantity of PMP and activation ratio of PAC-1 and CD62P(r=0.28,P=0.03 and r=0.61,P0.001 respectively).Conclusion:The levels of PMP,PAC-1 and CD62P can be taken as the specific laboratory indices for clinical diagnosis of ANFH.The quantity of PMP,activation ratio of PAC-1 and CD62P,and the index of hemorheology were markedly improved by using traditional Chinese medicine in ANFH patients." @default.
- W2353860254 created "2016-06-24" @default.
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- W2353860254 date "2012-01-01" @default.
- W2353860254 modified "2023-09-27" @default.
- W2353860254 title "Detection of the Platelet-derived Microparticles and Expression of GPIIb/IIIa and CD62P in Avascular Osteonecrosis of the Femoral Head before and after Treatment" @default.
- W2353860254 hasPublicationYear "2012" @default.
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