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- W2353861372 abstract "Aim In order to find new isoflavones with more potent antitumor activities by the introduction of substituted phenyl groups at position 3 of chromone with a 7-methoxyl or hydroxyl group.Methods The key intermediate 3-iodo-7-methoxyl-4H-chromen-4-one(5) was prepared from 2-hydroxyl-4-methoxyl-acetophenone and ethyl formate.The target compounds were synthesized by Suzuki coupling reaction of 5 and substituted phenylboronic acids.All of the target compounds were confirmed by 1H-NMR,MS and IR spectra respectively,some of them were also confirmed by 13C-NMR spectra.The IC50 of antitumor activity of target compounds were determined by the standard method using two kinds of human tumor cell lines,colon cancer cell HCT116 and liver cancer cell 7721.Results Twenty new compounds were designed and synthesized.The results of preliminary antitumor test show that all the target compounds exhibit potent antitumor activities to a certain extent except that the solubility of 4 compounds is too low to be tested.The activities of four target compounds are nearly same with that of curcumin and much more potent than that of genistein in vitro.Conclusion The antitumor activities of isoflavone anlogues can be promoted by introduction of different substituted phenyl groups at position 3 of chromone.It seems that it is favorable to the antitumor activity of target compound by introduction of small groups such as methyl,methoxyl and trifluoromethyl on the phenyl ring at position 3 of chromone." @default.
- W2353861372 created "2016-06-24" @default.
- W2353861372 creator A5084932840 @default.
- W2353861372 date "2010-01-01" @default.
- W2353861372 modified "2023-09-26" @default.
- W2353861372 title "Synthesis and antitumor activities of novel 3-(substituted phenyl) chromone derivatives" @default.
- W2353861372 hasPublicationYear "2010" @default.
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