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- W2353881330 abstract "Objective To explore the effects of Genistein on the proliferation and collagen synthesis of cultured human hypertrophic scar fibroblasts. Methods Human hypertrophic scar fibroblasts were cultured and stimulated by Genistein with concentration 25、50、100 μmol/L respectively and the control group is DMSO. The cellular proliferation was measured with the MTT staining method. The collagen synthesis was assessed by the 3 H-proline incorporation method. The expression of collagenⅠand collagen Ⅲ mRNA were evaluated by RT-PCR. Results Compared with control groups, Genistein can markedly inhibit the proliferation and collagen synthesis of cultured human hypertrophic scar fibroblasts (P0.05) and the inhibiting effects increased with increased drug dosage. Compared with the control group, the 100 μmol/L experimental group showed a highly significant difference (P0.01). Genistein also down-regulates the expression of collagen Ⅰand Ⅲ mRNAs (P0.05). Conclusion Genistein can inhibit the proliferation and biologic activity of hypertrophic scar fibroblasts and may become an effective drug for treatment of hypertrophic scar or fibrosis disease." @default.
- W2353881330 created "2016-06-24" @default.
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- W2353881330 date "2007-01-01" @default.
- W2353881330 modified "2023-09-23" @default.
- W2353881330 title "The effects of Genistein on the proliferation and collagen synthesis of hypertrophic scar fibroblasts in vitro" @default.
- W2353881330 hasPublicationYear "2007" @default.
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