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- W2353881852 abstract "Objective To study the antiangiogenic activity of polysaccharide-protein complex(PPC)from Scolopendra subspinipes mutilans. Methods Zebrafish model was used to evaluate vascular development defects of embryo by morphological observation,staining assay and quantitative endogenous alkaline phosphatase assay. Results PPC decreased the length of subintestinal vein(SIV) with inhibition ratio of 18.5%,31.3% and 42.4% at the concentration of 10.0,30.0 and 60.0mg/L,respectively.Treatment with PPC decreased vessel growth rate of zebrafish embryos and the level of mRNA expression of vascular endothelial growth factor(VEGF) in concentration-dependent manner. Conclusion PPC has significant antiangiogenic activity and the effects may be mediated by the inhibition of VEGF." @default.
- W2353881852 created "2016-06-24" @default.
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- W2353881852 date "2011-01-01" @default.
- W2353881852 modified "2023-09-22" @default.
- W2353881852 title "Inhibitory Effect of Polysaccharide-protein Complex from Scolopendra Subspinipes Mutilans on Angiogenesis of Zebrafish Embryo" @default.
- W2353881852 hasPublicationYear "2011" @default.
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