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- W2353896394 abstract "Objective:To investigate the accommodation and the molecular mechanism of Zuogui Pill(ZGP) on the proliferation and immuno function of rat thymocytes(MSTM) in vitro.Method:Thymocytes were divided into three groups:(A) control group;(B)model group;(C) ZGP group.The effect ZGP with corticosterone on the proliferation of thymocytes was detected by MTT.Cell cycle was measured by PI staining and FCM.The expression of p16,cdk4,IL-2,IL-2R were measured by Realtime PCR and Western Blotting.Results:Corticosterone had some inhibitory effect on thymocytes,arrested cell cycle at G_1 phase,up-regulated the expression of p16,down-regulated the expression of IL-2,IL-2R.Comparing with model group,ZGP group showed higher expression of IL-2 and IL-2R and lower expression of p16(P0.05).Conclusions:The possible mechanism of immuno-regulation effect of ZGP is to regulate the expression of p16,IL-2,IL-2Rα in MSTM,postpone the thymus dependented immune functional deterioration induced by corticosterone." @default.
- W2353896394 created "2016-06-24" @default.
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- W2353896394 date "2010-01-01" @default.
- W2353896394 modified "2023-09-24" @default.
- W2353896394 title "Study of Modulating Effect of ZuoGui Pill on Rat Thymocytes Proliferation" @default.
- W2353896394 hasPublicationYear "2010" @default.
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