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- W2353910616 abstract "【Objective】To explore the inhibition action induced by Tetramethylpyrazin(TMP) combined with cisplatin(DDP) on Lewis lung carcinoma in mice.【Methods】Lewis lung cancer cells were inoculated into the mammary fatty pad of C57BL/6 mice to establish Lewis lung carcinoma model,40 C57BL/6 mice bearing highly metastatic Lewis lung cancer cells were randomized into four groups: control group,DDP group,TMP group,TMP +DDP group.Different treatments were served from day 7 after transplantation and all mice were sacrificed after 19 days.During the treatment,the toxic side reaction of chemotherapy and the life quality were observed.Subcutaneous tumors were processed for tumor weight,and tumor growth inhibition rate and tumor necrosis rate of each group were calculated.【Results】In every treatment group tumor growth was suppressed significantly,intraperitoneal injection of DDP,TMP and their combination resulted in a significant inhibition on the growth of Lewis lung cancer cells in vivo(P0.01),the combination group showed significant enhancement in anti-tumor efficacy.Compared with DDP group,the tumor necrosis rate in combination group was significantly higher(P0.05),but not remarkably in TMP group(P0.05).Compared with DDP group,the toxic side reaction of chemotherapy in combination group was significantly lower,but life quality higher.(【Conclusion】)Combined application of Tetramethylpyrazin and Cisplatin has stronger inhibition on tumor growth than single use,and they have a synergic anticancer effect to Lewis lung cancer in mice,decrease toxic side reaction of chemotherapy and improve life quality." @default.
- W2353910616 created "2016-06-24" @default.
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- W2353910616 date "2006-01-01" @default.
- W2353910616 modified "2023-09-25" @default.
- W2353910616 title "Experimental Research on TMP Combination with DDP in Treating Lewis Lung Carcinoma" @default.
- W2353910616 hasPublicationYear "2006" @default.
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