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- W2353931991 abstract "Objective:To explore the regulation of Sodium copper chlorophyll in promoting MSC(mensenchymal stem cells,MSC) on T lymphocytes in immune-mediated AA(aplastic anemia,AA) mice.Method:To establish the immune-mediated AA mice model,all the mice were randomly divided into six groups including normal control group(N),AA model group(M),cyclosporin group(Cs),low-dose sodium copper chlorophyll group(X),the median-dose sodium copper chlorophyll group(Z) and high-dose sodium copper chlorophyll group(G).Each group had six mice and all the mice were killed after 15 days.Observe the bone marrow pathology of each group,bone marrow was given MSC culture and the third generation of MSCs were used to induce osteoblasts.The second generation of MSC(F2MSC) and morphological changes of osteoblasts were observed under light microscope.MSC adjusted phytohemagglutinin(PHA) on T lymphocyte transformation test and the transforming growth factor(TGF-β1) of MSC was measured by ELISA.Results:The bone marrow hyperplasia were more active in the groups of N,Cs,X,Z,G than those in M group.F2MSC were elongated spindle cells in each group.The third generation of MSC were induced into osteoblasts.The CD+25and FOXP+3 of N,X,Z,G groups were significantly higher than those of M group(P 0.05).The TGF-β1 of N,Cs,Z groups were significantly higher than those of M group(P0.05).Conclusion:Sodium copper chlorophyll can promote MSC to regulate T lymphocytes in AA mice." @default.
- W2353931991 created "2016-06-24" @default.
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- W2353931991 date "2012-01-01" @default.
- W2353931991 modified "2023-09-27" @default.
- W2353931991 title "Regulation of Sodium Copper Chlorophyll in Promoting Mesenchymal Stem Cells on T Lymphocytes in Immune-mediated AA Mice" @default.
- W2353931991 hasPublicationYear "2012" @default.
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