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- W2353938201 abstract "Objective To assess influence of local transfection of tissue factor pathway inhibitor gene on neointimal hyperplasia and protein-53(P53)expression in rabbit carotid artery after balloon injury.Methods 36 male New Zealand white rabbits were divided into three groups:saline,adenovirus-defect and adenovirus-defect carrying tissue factor pathway inhibitor gene treated group.Balloon catheter was used to induce injury to the carotid artery of rabbits and saline,adenovirus-defect and TFPI gene were locally delivered to injury site.14 days after procedures,the local injury vesseles were removed and harvested for pathological and immunohistochemical analysis.Expression of protein-53 was determined by using semiquantitive RT-PCR.Automatic image analysis system was used to detect the changes of neointimal,medium and luminal area.Results TFPI transfection could remarkably inhibit neointimal proliferation.The relative ratio of P53 mRNA was 1.31±0.14,1.27±0.11 and 4.21±0.87 in saline,adenovirus-defect and TFPI local transferring respectively.Comparied with saline and adenovius defect group,TFPI local transferring obviously increased P53 expression.Conclusion Local TFPI gene transfection can promote P53 expression and reduce neointimal hyperplasia in carotid artery of rabbits." @default.
- W2353938201 created "2016-06-24" @default.
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- W2353938201 date "2007-01-01" @default.
- W2353938201 modified "2023-09-23" @default.
- W2353938201 title "Local Transfection of Tissue Factor Pathway Inhibitor Gene on Neointimal Proliferation and Protein-53 Expression in Rabbit Carotid Artery After Balloon Injury" @default.
- W2353938201 hasPublicationYear "2007" @default.
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