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- W2353950715 abstract "Objective To evaluate the efficacy of continued entecavir(ETV) treatment 12 months for patients with hepatitis B e antigen(HBeAg)-positive chronic hepatitis B.Methods Between February 2006 and October 2006 of 46 patients with hepatitis B e antigen(HBeAg)-positive hepatitis B received entecavir(ETV) 0.5mg/d treatment in inpatient and outpatient departments of the first hospital of Quanzhou were retrospectively analysed.Results After 1 month treatment,54.35%(25/46) ALT levels recovered and 56.52%(26/46) achieved HBV DNA 1 000 copies/mL.Among patients treated for 12 months,95.65%(44/46) normalized ALT levels and 86.96%(40/46) achieved HBV DNA 1 000 copies/mL and 21.74%(10/46) achieved HBeAg/HBeAb seroconversion.The rate of ALT normalization were significant relate to the descendent amplitude of serum HBeAg titer in the first 3 months of treatment.Compared to the patients whose reduction of serum HBeAg titer higher than 90% in the 12th week,HBeAg/HBeAb seroconversion were significantly better than those lower than 90%(53% vs 3%,P0.05).Conclusions Entecavir can early and quickly and lastingly effect in viral suppression and ALT normalization.The descendent amplitude of serum HBeAg titer could early predict HBeAg/HBeAb seroconversion in entecavir(ETV) treatment for patients with hepatitis B e antigen(HBeAg)-positive CHB." @default.
- W2353950715 created "2016-06-24" @default.
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- W2353950715 date "2008-01-01" @default.
- W2353950715 modified "2023-09-28" @default.
- W2353950715 title "The Descendent Amplitude of Serum HBeAg Titer Predicts the Effect of Entecavir(ETV) Treatment for Patients with e Antigen(HBeAg)-Positive Chronic Hepatitis B" @default.
- W2353950715 hasPublicationYear "2008" @default.
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