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- W2353973373 abstract "Objective To analyze the abortion prevention effect of Tonifying-Kidney and Spleen Formula combined with progestin through a comparison of effectiveness and the success rate of abortion prevention with a therapy of single progestin on recurrent spontaneous abortion(RSA) patients. Methods Three hundred and forty eight patients with RSA history suffering from a threatened abortion at the clinic of our hospital were collected from Jan.2009 to Jan.2012.By a clinical study with non-randomized controlled trials,there were a total of 159 patients corresponded with RSA and kidney deficiency diagnostic criteria.They were divided into the treatment group(n=74 cases) and the control group(n=85 cases) based on whether they would like to accept the traditional Chinese medicine(TCM) dialectical therapy.Patients in the treatment group were treated with Tonifying-Kidney and Spleen Formula combined with progestin,while patients in the control group were given the single progestin treatment.Both groups took intervention therapies more than 2 weeks of eldest gestational age of pre-abortion.Six cases had fall off during the treatment(2 cases in the treatment group and 4 cases in the control group).The progesterone level after the treatment was monitored,to observe and compare the changes of progesterone level in the two groups before and after 2 weeks of treatment as well as adverse effects after taking the medicine.To evaluate the effectiveness rate of abortion prevention that was more than 2 weeks of eldest gestational age of pre-abortion,and the success rate of abortion prevention at follow-up,and the survival rate of embryo or fetus in both groups at different gestational period. ResultsThe progesterone level before treatment was(22.42±6.92) ng/mL in the treatment group,while it was(21.60±7.6) ng/mL in the control group,and the difference between the two groups had no statistical significance(P=0.489).The progesterone level after 2 weeks of treatment was(31.15±9.44) ng/mL in the treatment group,higher than that in the control group [(22.52±10.53) ng/mL],and the difference had statistical significance(P0.001).No obvious adverse effects appeared at follow-up after taking the medicine in the two groups.Sixty-five patients in the treatment group(90.3%) had effective abortion prevention,significantly higher than those in the control group(61 cases,75.3%),(P0.05).Fifty-one patients had successful abortion prevention in the treatment group(70.8%),significantly higher than those in the control group(43 cases,53.1%),(P0.05).The difference of fetal survival rate at 12-37 weeks between the two groups had statistical significance(P0.05). Conclusions The progesterone level in the treatment group rose significantly compared with that in the control group after the treatment.The effectiveness of Tonifying-Kidney and Spleen Formula combined with progestin is better than single progestin treatment.The fetal survival rate at 12-37 weeks in the treatment group was apparently higher than that in the control group.The Tonifying-Kidney and Spleen Formula combined with progestin was safe and effective." @default.
- W2353973373 created "2016-06-24" @default.
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- W2353973373 date "2013-01-01" @default.
- W2353973373 modified "2023-09-25" @default.
- W2353973373 title "The effect of Tonifying-Kidney and Spleen Formula combined with progestin on recurrent spontaneous abortion" @default.
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